CJC-1295 (With DAC)
CJC-1295 (With DAC)
Muscle Growth & Recovery
CJC-1295 (With DAC) is a synthetic peptide studied to better understand growth hormone-releasing hormone receptor signaling, extended peptide activity, pulsatile hormone release, and endocrine regulation.
- ✓ ≥99% purity
- ✓ Third-party COA
- ✓ US-synthesized
- ✓ Lyophilized powder
CJC-1295 (With DAC) is a synthetic, long-acting analog of growth hormone-releasing hormone (GHRH) studied for its influence on growth hormone and insulin-like growth factor 1 signaling pathways. The peptide incorporates a Drug Affinity Complex (DAC), which is designed to interact with circulating albumin and extend the compound’s stability and activity in laboratory models.
Research involving CJC-1295 examines GHRH receptor activation, pulsatile growth hormone signaling, downstream IGF-1 pathway activity, peptide pharmacokinetics, and albumin-binding delivery systems. Its extended research profile distinguishes it from shorter-acting GHRH analogs and makes it useful for investigating sustained endocrine signaling in laboratory and preclinical experimental settings.
CJC-1295 (With DAC) belongs to the growth hormone-releasing hormone analog family. It is based on the biologically active portion of human GHRH and contains several amino-acid substitutions designed to improve resistance to enzymatic degradation.
What distinguishes this compound from CJC-1295 without DAC—commonly known as Modified GRF (1-29)—is the addition of a Drug Affinity Complex. The DAC component contains a reactive maleimide group designed to bind covalently with circulating albumin in research models. This albumin interaction reduces the rate at which the compound is cleared and produces a substantially longer pharmacokinetic profile than non-DAC GHRH analogs.
In controlled research involving healthy adult subjects, CJC-1295 demonstrated sustained, dose-dependent effects on growth hormone and IGF-1 concentrations. Its extended activity has made the compound particularly relevant to research examining long-acting peptide design, pulsatile endocrine signaling, GHRH receptor biology, and the relationship between growth hormone and downstream IGF-1 pathways.
All CJC-1295 (With DAC) supplied through this repository is intended strictly for laboratory research, in-vitro experimentation, and scientific education. It is not formulated for human or veterinary administration.
- CAS Number: 446262-90-4
- Molecular Weight: Approximately 3647.2 g/mol
- Purity: ≥99%
- Also Known As: CJC-1295 DAC
- Chemical Formula: C₁₆₅H₂₆₉N₄₇O₄₆
In laboratory models, CJC-1295 (With DAC) acts as an agonist of the growth hormone-releasing hormone receptor, or GHRH-R. This G protein-coupled receptor is expressed primarily in pituitary somatotroph cell preparations. Receptor engagement activates intracellular cyclic adenosine monophosphate signaling pathways associated with the synthesis and release of growth hormone.
A defining feature of CJC-1295 is its Drug Affinity Complex. The DAC component is designed to form a covalent bond with albumin following exposure to biological media. Albumin binding protects the peptide from rapid enzymatic degradation and renal clearance, allowing researchers to examine prolonged receptor activity and sustained downstream signaling.
Unlike compounds that directly replace growth hormone, CJC-1295 is studied for its upstream interaction with GHRH receptors and its influence on endogenous pulsatile signaling patterns. Experimental research has examined the resulting changes in growth hormone activity, downstream IGF-1 signaling, and the duration of endocrine responses following GHRH-R activation.
- GHRH Receptor Biology
- Pulsatile Growth Hormone Signaling
- Growth Hormone and IGF-1 Pathway Research
- Long-Acting Peptide Development
- Endocrine Signaling Research
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Contact UsFor Research Use Only. Not for Human Consumption. Not a drug, supplement, or food product. All products are designated Research Use Only (RUO). Purchasers assume responsibility for ensuring compliance with all applicable regulations.