VIP - 10mg
VIP - 10mg
Neuropeptide & Cellular Signaling Research
VIP is a naturally occurring neuropeptide studied for its role in neural communication, vascular signaling, immune regulation, circadian biology, and smooth muscle activity.
- ✓ ≥99% purity
- ✓ Third-party COA
- ✓ US-synthesized
- ✓ Lyophilized powder
Vasoactive Intestinal Peptide (VIP) is a naturally occurring 28-amino-acid neuropeptide that functions as an important signaling molecule throughout the nervous system and numerous peripheral tissues. Despite its name, VIP is not limited to the gastrointestinal system and is widely distributed throughout the brain, autonomic nerves, cardiovascular system, respiratory tract, and other tissues.
VIP primarily produces its biological effects through interaction with the G protein-coupled receptors VPAC1 and VPAC2. Activation of these receptors can stimulate adenylate cyclase and increase intracellular cyclic AMP (cAMP), influencing a wide range of downstream cellular processes.
Research involving VIP spans several areas, including neural communication, vascular tone, smooth muscle activity, inflammatory signaling, immune-cell function, gastrointestinal physiology, and circadian regulation. VIP signaling is particularly notable within the suprachiasmatic nucleus, where it has been investigated for its role in coordinating cellular rhythms associated with the biological clock.
Because of its broad distribution and multiple receptor-mediated effects, VIP provides researchers with a versatile model for investigating communication between neural, immune, vascular, and endocrine-associated signaling pathways.
VIP, or Vasoactive Intestinal Peptide, is a 28-amino-acid regulatory peptide originally identified in intestinal tissue but subsequently found throughout both the central and peripheral nervous systems.
It belongs to a peptide family that includes PACAP, secretin, glucagon, and related signaling molecules. VIP acts primarily through VPAC1 (VIPR1) and VPAC2 (VIPR2) receptors, both of which are expressed across numerous cell and tissue types.
The peptide’s name reflects its ability to influence vascular and intestinal physiology, but subsequent research has demonstrated much broader biological activity. VIP participates in neural signaling, smooth-muscle regulation, secretion, vascular responses, immune-cell communication, and circadian synchronization.
Its diverse signaling profile makes VIP particularly useful for studying how a single endogenous neuropeptide can coordinate responses across multiple biological systems.
- CAS Number: 40077-57-4
- Molecular Weight: ~3,326.8 g/mol
- Purity: ≥99%
- Also Known As: Vasoactive Intestinal Polypeptide, VIP-28
- Chemical Formula: C₁₄₇H₂₃₇N₄₃O₄₃S
VIP exerts its primary signaling effects through the VPAC1 and VPAC2 receptors, members of the class B family of G protein-coupled receptors.
When VIP binds to these receptors, activation of G proteins can stimulate adenylate cyclase, increasing intracellular concentrations of cyclic adenosine monophosphate (cAMP). Elevated cAMP subsequently influences protein kinase A and other downstream signaling mechanisms capable of modifying cellular activity and gene expression.
The distribution of VPAC receptors varies among tissues. VPAC1 is expressed in numerous peripheral tissues and immune-cell populations, while VPAC2 has important roles within neural and neuroendocrine systems, including regions associated with circadian regulation.
Through these receptor pathways, researchers investigate VIP’s involvement in neuronal communication, smooth-muscle responses, vascular signaling, secretion, immune regulation, and synchronization of biological rhythms.
- Neural Signaling
- VPAC1 & VPAC2 Receptor Research
- Circadian Rhythm Research
- Vascular Signaling
- Immune & Inflammatory Signaling
- Gastrointestinal Research
- cAMP Signaling
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Contact UsFor Research Use Only. Not for Human Consumption. Not a drug, supplement, or food product. All products are designated Research Use Only (RUO). Purchasers assume responsibility for ensuring compliance with all applicable regulations.