Cagrilintide
Cagrilintide
Weight Management & Metabolism
Cagrilintide is an amylin analog that works alongside metabolic peptides to regulate appetite and satiety. It is commonly studied for its role in enhancing fullness and supporting weight management protocols.
- ✓ ≥99% purity
- ✓ Third-party COA
- ✓ US-synthesized
- ✓ Lyophilized powder
Cagrilintide is studied to better understand satiety signaling, gastric motility regulation, and how amylin receptor pathways influence appetite and metabolic balance.
Cagrilintide belongs to a structurally distinct class of metabolic peptide analogs — the amylin mimetics — which operate through a receptor pathway entirely separate from the incretin axis targeted by GLP-1 and GIP agonists. Where GLP-1R and GIPR engagement drives pancreatic insulin secretion signaling, amylin receptor activation works primarily through hypothalamic and brainstem circuits, influencing satiety signaling, gastric motility, and glucagon suppression pathways in preclinical neural and gastrointestinal cell models.
Its long-acting profile — achieved through fatty acid acylation — makes it a particularly useful tool compound for studying sustained amylin receptor occupancy and the downstream signaling consequences of prolonged CTR/RAMP complex activation.
- CAS Number: 1415456-99-3
- Molecular Weight: ~4,409.0 g/mol
- Purity: ≥99%
- Also Known As: INN: Cagrilintide, AM833 (development code), Long-acting amylin analog, CTR/RAMP agonist
- Chemical Formula: C₁₉₄H₃₁₂N₅₄O₅₉S₂
In cell-based and preclinical models, Cagrilintide binds to amylin receptors — heterodimeric complexes of the calcitonin receptor (CTR) paired with receptor activity-modifying proteins RAMP1, RAMP2, or RAMP3 — expressed across hypothalamic, brainstem, and peripheral tissue preparations. Receptor engagement activates Gs-coupled cAMP signaling cascades, with downstream effects on neuronal activity patterns associated with satiety signaling and food intake regulation in central nervous system cell models.
In gastric and gastrointestinal preparations, CTR/RAMP complex activation has been associated with measurable changes in gastric motility signaling markers — consistent with the gastric emptying delay observed in amylin receptor activation models. In pancreatic alpha-cell preparations, amylin receptor signaling has been linked to glucagon suppression through mechanisms studied alongside GLP-1-mediated paracrine pathways.
Cagrilintide’s acylation-mediated extended half-life allows for sustained receptor occupancy studies in laboratory preparations — a feature that distinguishes it from native amylin’s rapid clearance profile and makes it a more experimentally controllable tool compound for long-duration receptor signaling assays.
- Amylin Receptor Biology
- Satiety Signaling Research
- Gastric Motility Pathway Studies
- Glucagon Suppression Modeling
- Long-Acting Analog Pharmacology
- Multi-Pathway Metabolic Signaling
- Receptor Activity-Modifying Protein Studies
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