CJC-1295 (NO DAC) + Ipamorelin
CJC-1295 (NO DAC) + Ipamorelin
Muscle Growth & Recovery
This peptide combination works to stimulate natural growth hormone release. It is widely researched for its potential benefits in recovery, sleep quality, lean muscle support, and overall vitality.
- ✓ ≥99% purity
- ✓ Third-party COA
- ✓ US-synthesized
- ✓ Lyophilized powder
CJC-1295 (No DAC) + Ipamorelin is studied to better understand how two separate growth hormone receptor pathways work together to influence GH release and pulse dynamics.
CJC-1295 (No DAC) and Ipamorelin each occupy distinct positions on the growth hormone secretion axis, engaging separate receptor systems that converge on pituitary somatotroph GH release through complementary intracellular signaling mechanisms.
CJC-1295 (No DAC) is a modified tetradecapeptide GHRH analog — structurally derived from the first 29 amino acids of endogenous GHRH — engineered for improved receptor binding stability relative to native GHRH while retaining its natural short acting duration. The absence of the Drug Affinity Complex (DAC) technology distinguishes this variant from the longer-acting CJC-1295 with DAC, producing a pulsatile GH release profile in laboratory models more closely resembling physiological secretion patterns. This distinction is relevant for researchers designing experiments around pulse dynamics versus sustained GH axis stimulation.
Ipamorelin is a selective pentapeptide GHS-R1a agonist notable for its receptor selectivity — unlike earlier GHRPs such as GHRP-6, Ipamorelin demonstrates minimal activity at cortisol and prolactin-related receptor systems in preclinical assay models, making it a cleaner pharmacological tool for isolating GHS-R1a-specific signaling outcomes.
- CAS Number: CJC-1295 (No DAC): 446262-90-4 Ipamorelin: 170851-70-4
- Molecular Weight: CJC-1295 (No DAC): ~3367.95 g/mol, Ipamorelin: 711.86 g/mol
- Purity: ≥99%
- Also Known As: CJC-1295 (No DAC): Modified GRF(1-29), Mod GRF 1-29 Sermorelin analog, Ipamorelin: NNC 26-0161 Ipamorelin acetate, GHRH/GHRP combination blend
- Chemical Formula: CJC-1295 (No DAC): C₁₄₉H₂₄₆N₄₄O₄₂ , Ipamorelin: C₃₈H₄₉N₉O₅
In cell-based and preclinical models, the two components of this blend engage the GH secretion axis through distinct but convergent receptor pathways.
When both peptides are applied together, the simultaneous activation of cAMP/PKA (via GHRHR) and calcium/PKC (via GHS-R1a) signaling cascades in somatotroph preparations produces GH release responses consistent with pharmacological synergy — exceeding the outputs of either compound at equivalent concentrations in isolation. This dual-pathway convergence on GH granule exocytosis is the primary mechanistic rationale for studying this combination in GH axis pharmacology research.
- GH-Axis Synergy Research
- GHRHR Receptor Biology
- GHS-R1a Receptor Pharmacology
- Dual Intracellular Pathway Research
- GHS-R1a Selectivity Studies
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Contact UsFor Research Use Only. Not for Human Consumption. Not a drug, supplement, or food product. All products are designated Research Use Only (RUO). Purchasers assume responsibility for ensuring compliance with all applicable regulations.
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