Kisspeptin
Kisspeptin
Sexual Health & Hormone Support
Kisspeptin-10 is studied to better understand reproductive hormone signaling, GnRH neuron activation, and the molecular pathways that regulate fertility and puberty.
- ✓ ≥99% purity
- ✓ Third-party COA
- ✓ US-synthesized
- ✓ Lyophilized powder
Kisspeptin is a naturally occurring peptide that plays a major role in regulating reproductive hormones, fertility, and sexual wellness. It works by stimulating the release of key hormones involved in testosterone production, ovulation, libido, and overall hormonal balance.
Kisspeptin-10 (KP-10) is the shortest naturally occurring isoform of the kisspeptin family, sharing the conserved C-terminal sequence common to the 54, 13, and 14 amino acid variants. It is cleaved from a 145 amino acid KISS1 precursor protein and represents the core pharmacophore responsible for GPR54 receptor engagement.
Among the kisspeptin isoforms, KP-10 is the most potent at receptor level, though it carries a plasma half-life approximately six times shorter than KP-54 — a distinction relevant to in-vitro kinetic studies and receptor occupancy modeling. It is produced endogenously by trophoblast cells during early pregnancy in human tissue models, where it has been observed to influence cell migration behavior in primary trophoblast preparations.
GPR54 (Kiss1r) is expressed broadly across GnRH neurons and in peripheral tissues, which has broadened research interest in Kisspeptin-10 beyond reproductive endocrinology into other receptor biology domains. All product supplied here is intended exclusively for controlled laboratory and research settings.
- CAS Number: 374675-21-5
- Molecular Weight: 1302.49 Da
- Purity: ≥99%
- Also Known As: KP-10, Kisspeptin-10 human, Metastin (45–54), Kiss-1 (112–121) human, Kisspeptin-13 (4–13) human, KISS1 gene product C-terminal fragment, H-YNWNSFGLRF-NH2
- Chemical Formula: C₆₃H₈₃N₁₇O₁₄
In cell-based and preclinical models, Kisspeptin-10 binds with high affinity to GPR54, a G protein-coupled receptor expressed on GnRH neurons in the hypothalamus. Receptor engagement activates downstream IP3 signaling cascades, triggering GnRH neuron firing and the subsequent stimulation of gonadotropin release — specifically LH and FSH — from pituitary preparations.
Research models have demonstrated that Kisspeptin-10 acts upstream of GnRH neurons rather than directly at the pituitary level.
- GPR54 Receptor Studies
- Brain-Hormone Communication
- Hormone Release Dynamics
- Reproductive Biology Research
- Hormonal Deficiency Pathway Modeling
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* Endotoxin Testing
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Contact UsFor Research Use Only. Not for Human Consumption. Not a drug, supplement, or food product. All products are designated Research Use Only (RUO). Purchasers assume responsibility for ensuring compliance with all applicable regulations.
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