Semax
Semax
Brain & Mood (Nootropics)
Semax is a nootropic peptide derived from ACTH fragments. It is commonly studied for cognitive support, including memory, focus, and neuro protection.
- ✓ ≥99% purity
- ✓ Third-party COA
- ✓ US-synthesized
- ✓ Lyophilized powder
Semax is studied to better understand neurotrophic signaling, brain growth factor regulation, and neuroprotective pathways involved in cell survival.
Semax belongs to a class of ACTH-derived peptide analogs developed to isolate the neurotrophic and neuroprotective signaling properties of the ACTH(4-7) sequence without engaging the adrenal steroidogenic axis. Its Pro-Gly-Pro C-terminal extension — a naturally occurring neuropeptide sequence in its own right — contributes additional protease resistance and has been associated with independent neurotrophic activity in CNS tissue preparations, making the full Semax sequence more than a simple ACTH fragment.
What distinguishes Semax as a research tool compound is the breadth of its CNS signaling profile. Its primary research characterization centers on BDNF and NGF pathway upregulation in hippocampal and cortical cell preparations — neurotrophic factors studied for their roles in synaptic plasticity, neuronal survival signaling, and long-term potentiation models. Beyond neurotrophic factor modulation, Semax has been investigated in cerebral ischemia models for anti-apoptotic and antioxidant signaling activity, adding a neuroprotective research dimension alongside its neurotrophic profile.
- CAS Number: 80714-61-0
- Molecular Weight: 813.92 g/mol
- Purity: ≥99%
- Also Known As: MEHFPGP ,ACTH(4-7)PGP, N-Pro-Gly-Pro-ACTH(4-7), Semax acetate (salt form in some preparations)
- Chemical Formula: C₃₇H₅₁N₉O₁₀S
In cell-based and preclinical CNS models, Semax’s primary characterized mechanism involves upregulation of BDNF and NGF expression in hippocampal and cortical tissue preparations. RT-PCR and Northern blot analysis in rodent hippocampal preparations following Semax exposure have documented 1.6- to 2.2-fold increases in BDNF mRNA and corresponding mature BDNF protein elevation in CA1 and cortical layer II-III neurons, alongside compensatory TrkB receptor upregulation consistent with elevated neurotrophic ligand availability.
The downstream signaling consequences of BDNF/TrkB pathway upregulation — including MAPK/ERK and PI3K/Akt cascade activation — are well characterized in synaptic plasticity and neuronal survival research models, making Semax a useful upstream tool compound for studying how neurotrophic factor availability influences these pathways in CNS preparations.
- BDNF and NGF Expression Studies
- Synaptic Plasticity Modeling
- Neuroprotective Signaling Research
- Apoptotic Cascade Studies
- Oxidative Stress and Lipid Peroxidation Models
- ACTH Fragment Pharmacology
- Peptide CNS Delivery Research
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Contact UsFor Research Use Only. Not for Human Consumption. Not a drug, supplement, or food product. All products are designated Research Use Only (RUO). Purchasers assume responsibility for ensuring compliance with all applicable regulations.
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